- osteopenia, obesity feedback via hypothalamus stimulation via OCT injection
- thymus and t cell immunity axis
- muscle repair via stem cell stimulation
- 1 rat experiment- appears over expression of liver enzyme of oxytocinase is responsible for OCT destruction.
Muscle repair via stem cell stimulation
A blog intro- http://blogs.discovermagazine.com/science-sushi/2014/06/27/new-study-shows-muscles-love-oxytocin/#.U7Jh-EBCBow
Careful here - "When the team looked closely at what was happening in the regenerating
muscle cells, they found that oxytocin turns on a well-known cellular
cascade that triggers growth and proliferation: the MAPK/ERK signaling pathway. "
The Starting point
http://www.ncbi.nlm.nih.gov/pubmed/24915299 Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.
The
regenerative capacity of skeletal muscle declines with age. Previous
studies suggest that this process can be reversed by exposure to young
circulation; however, systemic age-specific factors responsible for this
phenomenon are largely unknown. Here we report that oxytocin-a hormone
best known for its role in lactation, parturition and social
behaviours-is required for proper muscle tissue regeneration and
homeostasis, and that plasma levels of oxytocin decline with age.
Inhibition of oxytocin signalling in young animals reduces muscle
regeneration, whereas systemic administration of oxytocin rapidly
improves muscle regeneration by enhancing aged muscle stem cell
activation/proliferation through activation of the MAPK/ERK signalling
pathway. We further show that the genetic lack of oxytocin does not
cause a developmental defect in muscle but instead leads to premature
sarcopenia. Considering that oxytocin is an FDA-approved drug, this work
reveals a potential novel and safe way to combat or prevent skeletal
muscle ageing.
Rate : 1microgram of OCT per gram of mouse ie 1miligram per kg of mouse ie 80mg per 80 kg mouse. Roughly equals 2mg per 80kg human using surface area multiplier.
Osteopenia and Obesity
Thus, OT constitutes an effective strategy for targeting osteopenia, overweight, and fat mass redistribution without any detrimental effects in a mouse model mimicking the menopause
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658979/
Here, based on a randomized pilot clinical trial, we report that intranasal oxytocin administration over an 8-week period led to effective reduction of obesity and reversal of related prediabetic changes in patients.
http://www.ncbi.nlm.nih.gov/pubmed/19479077
PLoS One. 2009 May 22;4(5):e5668. doi: 10.1371/journal.pone.0005668.
Elabd C1, Cousin W1, Upadhyayula P2, Chen RY2, Chooljian MS2, Li J2, Kung S2, Jiang KP2, Conboy IM2.
Author information
- 11] Department of Bioengineering, Stem Cell Center, QB3 Institute, UC Berkeley, Berkeley, California
Abstract
Rate : 1microgram of OCT per gram of mouse ie 1miligram per kg of mouse ie 80mg per 80 kg mouse. Roughly equals 2mg per 80kg human using surface area multiplier.
Low Oxytocin, Liver and Oxytocinase Activity
from this paper J Endocrinol. 2014 Feb 10;220(3):333-43.
Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue.
http://www.ncbi.nlm.nih.gov/pubmed/24389591
"Obese Zucker rats displayed a marked reduction in plasma oxytocin levels. Elevated liver and adipose tissue oxytocinase activity was noticed in obese Zucker rats. Hypothalamic oxytocin gene expression was not altered by the obese phenotype. OXTR mRNA and protein levels were upregulated in the adipose tissue of obese animals in contrast to the reduced OXTR protein levels in skeletal muscle. Our results show that obesity is associated with reduced plasma oxytocin due to increased peptide degradation by liver and adipose tissue rather than changes in hormone synthesis. This study highlights the importance of the oxytocin system in the pathogenesis of obesity and suggests oxytocinase inhibition as a candidate approach in the therapy of obesity."Osteopenia and Obesity
Endocrinology. 2014 Apr;155(4):1340-52.
Oxytocin reverses ovariectomy-induced osteopenia and body fat gain.
http://www.ncbi.nlm.nih.gov/pubmed/24506069Thus, OT constitutes an effective strategy for targeting osteopenia, overweight, and fat mass redistribution without any detrimental effects in a mouse model mimicking the menopause
Treatment of Obesity and Diabetes Using Oxytocin or Analogs in Patients and Mouse Models
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658979/
Here, based on a randomized pilot clinical trial, we report that intranasal oxytocin administration over an 8-week period led to effective reduction of obesity and reversal of related prediabetic changes in patients.
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| Human data |
http://iv.iiarjournals.org/content/24/2/157.full.pdf
Abstract.
Background: It has been shown that the
neurohypophyseal peptide oxytocin is present in the human
thymus and in vitro it can mimic interleukin (IL)-2 action in
the induction of interferon-γ production.he present results support the hypothesis that neuropeptides
may act as a link in the network between the immune and the
neuroendocrine systemshttp://www.ncbi.nlm.nih.gov/pubmed/19479077
PLoS One. 2009 May 22;4(5):e5668. doi: 10.1371/journal.pone.0005668.
Impact of growth hormone (GH) deficiency and GH replacement upon thymus function in adult patients.
Morrhaye G1, Kermani H, Legros JJ, Baron F, Beguin Y, Moutschen M, Cheynier R, Martens HJ, Geenen V.
