Lucy,a 15 yo jack russell terrier has severe, almost life threatening , occasional bouts of colitis, preceded with mucus on stools.over a 2 day cycle. Broccoli at dinner is a favoured part of her diet. Can we learn from this preference for a green vegetable?
Enter last night this murine model paper- “Preventive and therapeutic effects of nitrite supplementation in experimental inflammatory bowel disease” http://www.sciencedirect.com/science/article/pii/S2213231713001006
Highlights
• Inorganic nitrate and nitrite alleviate DSS-induced colitis.
• Dietary nitrite has therapeutic effects in already established colonic inflammation.
• DSS-induced thinning of the colonic mucus layer is prevented by dietary nitrite.
• Nitrite promotes healing of colon epithelial cells.
Now the interesting part is that circulating nitrate is converted by bacteria on the tongue to nitrite! http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575935/
“The site of nitrate reduction to nitrite in humans is almost exclusively on the posterior third of the tongue, by nitrate reductase‐containing symbiotic bacteria, predominantly Veillonella species, as well as Actinomyces, Rothia and Staphylococcus epidermidis [b117,b118]. Whilst some conversion of nitrate to nitrite occurs on the ‘first pass’ of nitrate‐containing food over the surface of the tongue before it is initially swallowed, the majority of nitrate reduction to nitrite occurs over the subsequent few hours, via the entero‐salivary circulation [1], following concentration of nitrate in the salivary glands, and secretion in saliva, as described above [107,113,115,116].
So the experiment started last night- to lift the amount of nitrate in food and test the palatibility of foods; last night, first test – smoked salmon- eaten with relish. This morning, wilted lettuce with smoked salmon – eaten with relish. So we keep going with finding interesting sources of dietary nitrates.
As an aside, while there is strong interest in repairing the effect of episodic bouts of antibiotics on gut flora, I am increasingly interested in the prospects of continuous insults to flora, via ” innocuous” chloroamines in drinking water to oral bacteria ecology and the reaction in the stomach of amine and nitro compounds.
Now this little story gives a little encouragement to examine the life cycle of dietary recommendations for humans. An example is outlined in this abstract http://www.ncbi.nlm.nih.gov/pubmed/19439460
“Food sources of nitrates and nitrites: the physiologic context for potential health benefits”. The suggested intake is up to 550% greater than guidelines.
Background Notes for oral biome
DSS Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks DSS is a polysaccharide with various MW supplies. Different effects occur with different MW.
Oral bacteria thread , excellent
H Pyroli uses nickel in its enzymes , Stores it, and nickel can come from Stainless steel cutlery and pots
Sepiapterin ameliorates chemically induced murine colitis and azoxymethane-induced colon cancer
C60 forum
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