Monday, 7 July 2014

Structured Interfacial Water

Extra Low Frequency Magnetic Fields alter Cancer Cells through Metabolic Restriction Ying Li Paul Héroux InVitroPlus Laboratory, Department of Surgery, Royal Victoria Hospital, Montreal Montreal, Canada
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein1
Jerry Pollack Lecture and book

Tuesday, 1 July 2014

Oxytocin: An Aged Muscle Repair Assistant Agent?

Thesis 2014: Oxytocin , is FDA approved. Previously thought of a hormone for lactation and social behaviors is advancing on a front driven by the realization that OCT receptors are throughout the body. Current studies are

osteopenia, obesity feedback via hypothalamus stimulation via OCT injection
thymus and t cell immunity axis
muscle repair via stem cell stimulation
1 rat experiment- appears over expression of liver enzyme of oxytocinase is responsible for OCT destruction.

Muscle repair via stem cell stimulation

A blog intro- http://blogs.discovermagazine.com/science-sushi/2014/06/27/new-study-shows-muscles-love-oxytocin/#.U7Jh-EBCBow

Careful here - "When the team looked closely at what was happening in the regenerating muscle cells, they found that oxytocin turns on a well-known cellular cascade that triggers growth and proliferation: the MAPK/ERK signaling pathway. "

The Starting point

http://www.ncbi.nlm.nih.gov/pubmed/24915299 Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.

Elabd C¹, Cousin W¹, Upadhyayula P², Chen RY², Chooljian MS², Li J², Kung S², Jiang KP², Conboy IM².

Author information

¹1] Department of Bioengineering, Stem Cell Center, QB3 Institute, UC Berkeley, Berkeley, California

Abstract

The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown. Here we report that oxytocin-a hormone best known for its role in lactation, parturition and social behaviours-is required for proper muscle tissue regeneration and homeostasis, and that plasma levels of oxytocin decline with age. Inhibition of oxytocin signalling in young animals reduces muscle regeneration, whereas systemic administration of oxytocin rapidly improves muscle regeneration by enhancing aged muscle stem cell activation/proliferation through activation of the MAPK/ERK signalling pathway. We further show that the genetic lack of oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia. Considering that oxytocin is an FDA-approved drug, this work reveals a potential novel and safe way to combat or prevent skeletal muscle ageing.

Rate : 1microgram of OCT per gram of mouse ie 1miligram per kg of mouse ie 80mg per 80 kg mouse. Roughly equals 2mg per 80kg human using surface area multiplier.

Low Oxytocin, Liver and Oxytocinase Activity

from this paper J Endocrinol. 2014 Feb 10;220(3):333-43.

Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue.

http://www.ncbi.nlm.nih.gov/pubmed/24389591

"Obese Zucker rats displayed a marked reduction in plasma oxytocin levels. Elevated liver and adipose tissue oxytocinase activity was noticed in obese Zucker rats. Hypothalamic oxytocin gene expression was not altered by the obese phenotype. OXTR mRNA and protein levels were upregulated in the adipose tissue of obese animals in contrast to the reduced OXTR protein levels in skeletal muscle. Our results show that obesity is associated with reduced plasma oxytocin due to increased peptide degradation by liver and adipose tissue rather than changes in hormone synthesis. This study highlights the importance of the oxytocin system in the pathogenesis of obesity and suggests oxytocinase inhibition as a candidate approach in the therapy of obesity."

Osteopenia and Obesity

2014 Apr;155(4):1340-52.

Oxytocin reverses ovariectomy-induced osteopenia and body fat gain.

http://www.ncbi.nlm.nih.gov/pubmed/24506069
Thus, OT constitutes an effective strategy for targeting osteopenia, overweight, and fat mass redistribution without any detrimental effects in a mouse model mimicking the menopause

Treatment of Obesity and Diabetes Using Oxytocin or Analogs in Patients and Mouse Models

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658979/

Here, based on a randomized pilot clinical trial, we report that intranasal oxytocin administration over an 8-week period led to effective reduction of obesity and reversal of related prediabetic changes in patients.


Human data

http://iv.iiarjournals.org/content/24/2/157.full.pdf

Abstract.

Background: It has been shown that the

neurohypophyseal peptide oxytocin is present in the human

thymus and in vitro it can mimic interleukin (IL)-2 action in

the induction of interferon-γ production.he present results support the hypothesis that neuropeptides

may act as a link in the network between the immune and the

neuroendocrine systems
http://www.ncbi.nlm.nih.gov/pubmed/19479077

2009 May 22;4(5):e5668. doi: 10.1371/journal.pone.0005668.

Impact of growth hormone (GH) deficiency and GH replacement upon thymus function in adult patients.

Morrhaye G¹, Kermani H, Legros JJ, Baron F, Beguin Y, Moutschen M, Cheynier R, Martens HJ, Geenen V.

Author information

Abstract

BACKGROUND:

Despite age-related adipose involution, T cell generation in the thymus (thymopoiesis) is maintained beyond puberty in adults. In rodents, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and GH secretagogues reverse age-related changes in thymus cytoarchitecture and increase thymopoiesis. GH administration also enhances thymic mass and function in HIV-infected patients. Until now, thymic function has not been investigated in adult GH deficiency (AGHD). The objective of this clinical study was to evaluate thymic function in AGHD, as well as the repercussion upon thymopoiesis of GH treatment for restoration of GH/IGF-1 physiological levels.

METHODOLOGY/PRINCIPAL FINDINGS:

Twenty-two patients with documented AGHD were enrolled in this study. The following parameters were measured: plasma IGF-1 concentrations, signal-joint T-cell receptor excision circle (sjTREC) frequency, and sj/beta TREC ratio. Analyses were performed at three time points: firstly on GH treatment at maintenance dose, secondly one month after GH withdrawal, and thirdly one month after GH resumption. After 1-month interruption of GH treatment, both plasma IGF-1 concentrations and sjTREC frequency were decreased (p<0.001). Decreases in IGF-1 and sjTREC levels were correlated (r = 0.61, p<0.01). There was also a decrease in intrathymic T cell proliferation as indicated by the reduced sj/beta TREC ratio (p<0.01). One month after reintroduction of GH treatment, IGF-1 concentration and sjTREC frequency regained a level equivalent to the one before GH withdrawal. The sj/beta TREC ratio also increased with GH resumption, but did not return to the level measured before GH withdrawal.

CONCLUSIONS:

In patients with AGHD under GH treatment, GH withdrawal decreases thymic T cell output, as well as intrathymic T cell proliferation. These parameters of thymus function are completely or partially restored one month after GH resumption. These data indicate that the functional integrity of the somatotrope GH/IGF-1 axis is important for the maintenance of a normal thymus function in human adults.

TRIAL REGISTRATION:

ClinicalTrials.gov NTC00601419.

HRV Early Explorations for AntiAging Clinicians

Wednesday, 25 June 2014

Plant Offal

Monday June 30th 2014

Dear M

It was a joy to see your face light up when I mentioned " Plant Offal" yesterday in Healesville!

naturally I cant find the actual story that used the term " plant offal"- its a good name

here are some links to that storyline....

http://www.u.tv/Entertainment/This-Mornings-Food-Waste-Recipes/cbc3b95b-9027-46dd-a693-4308652d11a3

http://www.dailymail.co.uk/news/article-2637936/Dont-bin-onion-skins-cut-blood-pressure-Inedible-prevent-arteries-closing-added-stock.html

http://one-vibration.com/profiles/blogs/eating-banana-peels-will-make-you-amazingly-healthy#.U7FETUBCBow

http://www.vegrecipesofindia.com/banana-peel-thoran/

and here is a link to a wonderful dementia story airing on Australian Story now- both on Rupert Murdoch's tabloid paper out of the UK!

Maybe Rupert should ask to become your new best friend.

http://www.dailymail.co.uk/news/article-2674496/Woman-survived-20-years-dementia-new-love-astonishes-doctors.html

all the best!

Thursday, 12 June 2014

June 2014 resources

Monday, 26 May 2014

Nitrite skin bacteria gemma

http://www.nytimes.com/2014/05/25/magazine/my-no-soap-no-shampoo-bacteria-rich-hygiene-experiment.html?smid=pl-share
my-no-soap-no-shampoo-bacteria-rich-hygiene-experiment.

Gemma says:

May 24, 2014 at 01:04

There was perhaps too much nitrogen in my original comment, so here goes some science to de-confuse the dear reader (on the interplay of sun, nitrogen, ammonia-oxidizing bacteria and CVD health):
Is sunlight good for our heart?
“We propose here that many of the beneficial effects of sunlight, particularly those related to cardiovascular health, are mediated by mechanisms that are independent of melatonin, vitamin D, and exposure to UVB alone. Specifically, we suggest that the skin is a significant store of nitric oxide (NO)-related species that can be mobilized by sunlight and delivered to the systemic circulation to exert coronary vasodilator and cardioprotective as well as antihypertensive effects (Figure 1). We further hypothesize that this dermal NO reservoir is a product of local production and dietary supply with nitrate-rich foods.
[...]
A recent human study has demonstrated that UVA irradiation can increase plasma nitrite levels by 40%. This is intriguing considering that in animal models, a similar increase in nitrite is associated with cardioprotection following I/R injury. Dietary nitrate intake (predominantly from green leafy vegetables) may provide an alternative source of nitrite.”
http://eurheartj.oxfordjournals.org/content/early/2010/03/09/eurheartj.ehq069.full

Gemma says:

May 24, 2014 at 01:22

And now on the importance of the ammonia oxidising bacteria (AOB) living on the skin:
Soil bacteria, nitrite and the skin
“Mammals likely evolved with AOB on their skin, providing their host with nitrite by conversion of ammonia in providing their host with nitrite by conversion of ammonia in sweat with scalp, pubic and underarm hair providing a suitable niche due to enhanced sweat production, increased warmth, increased relative humidity and protection of light (the latter is important as ammonia monooxygenase activity is inhibited by light). Low NO increases androgen levels which increase growth of pubic hair, expanding the AOB niche thereby increasing NO/NOx production and absorption in a feedback loop.
The production of a suitable niche for these bacteria provides a rationale for non-thermal sweating (e.g., under stress) (to supply NO/nitrites, the location of body hair (near lymph nodes), why the skin of the scalp is thin and well vascularized (to enhance NO/nitrite absorption), any why the sweat glands are most abundant on the feet and palms (fro antimicrobial effects of acidified nitrite in surfaces in contact with soil).
http://www.researchgate.net/publication/227124248_Soil_bacteria_nitrite_and_the_skin
(full text available)

Monday, 19 May 2014

Nick May 2014

IC portal
Viper forum
betfair
Jarratd davis canadian druid teacher
Nicks Viper

Tuesday, 29 April 2014

Seth Died post Easter 2014

Seth died last Sunday April 27th 2014.

This is one of the best posts in his blog from an ordinary citizen scientist

Journal of Personal Science: Molybdenum and Avoiding Sulfur Helped My IBS

by August Hurtel

I live in Shreveport, Louisiana and work in the interlibrary loans department at Shreve Memorial library. I am 39 years old.
I believe, due to experiences I will expand upon below, that excess sulfur compounds, especially sulfites, may contribute to and even cause irritable bowel syndrome (IBS). If you have IBS, you can try to verify this in a few ways.
1) Try molybdenum. I take Carlson Lab’s Moly-B 500 mcg tablets (one tablet/day).
2) Avoid foods and supplements high in sulfur.
3) If you have already purchased the services of 23&me or want to, you can look at this thread in the forums — “Reactions to food containing sulfites, sulfur dioxide, bisulfite, metabisulfite. SUOX gene” — and see if you have the same polymorphisms, though if you just do the first two, you’ll be able to guess.
The woman who started that thread at 23&me goes by the name Red Ringlets. She asked if anyone with four polymorphisms involved in sulfur processing experience reactions to sulfur compounds commonly added to foods as preservatives and/or for antibacterial purposes. I have three of these polymorphisms. I knew I was allergic to certain medicines, but I had not thought about the effect of sulfur coming from my food and supplements largely because I associated reactions to sulfur with hives and headaches.
Several years ago once the appetite suppression the Shangri-La diet kicked in, I adopted what most would consider a paleo template for my diet. This means I generally avoid grains, legumes, and dairy with caveats (like rice, now that I work out, and butter because it is animal fat and therefore good according to evolutionary thinking). Additionally a substantial amount of the meat that I buy comes from conventional sources.
Despite not being technically paleo, I enjoyed coffee, chocolate, and red wine, which are all high in sulfur. Sulfur is also added to various coconut products, shrimp, fish, dried fruit — many products a person trying to eat paleo might eat. I ate them. And I would have gastrointestinal distress that I could not explain despite getting leaner.
In the summer of 2013 after a few social functions that served grilled hamburgers, grilled shrimp, and other summer party foods a paleo dieter might think would be okay, I went to the emergency room. I had a serious pain where my appendix should be. Sometimes the pain would get worse after eating, and I would often get diarrhea. I thought I had appendicitis, but the doctors found nothing wrong. They took regular X-rays and did blood tests, and came back and said they found nothing. I got really angry about that, so they ordered a CT scan. The CT scan also showed nothing. They told me I had IBS because they had gone through a list of other things it might be and eliminated all of them.
When I went to the emergency room, I also inadvertently took with me a large amount of sulfur. I had a couple of 90% Lindt bars with me. My chocolate intake had risen during that time, too. I had stuff to do, places to go — and an excuse to treat chocolate like a food group.
I was aware, from reading on the internet, of FODMAPs, which are osmotic carbohydrates that draw water into the gut, causing gas, bloating, cramping and diarrhea. They seemed a likely culprit because these were the symptoms I experienced. Following a low FODMAP diet seemed to help, but not perfectly so.
There is some overlap between the two lists of foods to avoid (high sulfur and high FODMAP), so avoiding FODMAPs might have helped because it made me avoid sulfur. It also made it possible for me to have days where I didn’t eat any FODMAP foods but I would eat something like shrimp and then I’d have symptoms despite not eating any FODMAPs. So, looking back on it, I think of attending a wedding, eating nothing but shrimp, and drinking a little bit of red wine, and then having IBS problems and not understanding why because it doesn’t fit in well with the FODMAP story. I think FODMAPs are problematic in a gut that has already been compromised, but FODMAPs are not evolutionarily novel, and thus are unlikely to be the original cause of the problem.
Since it was summer and I just gotten through that ER experience, I stopped eating a lot of fruits, chocolate, wine, etc. One of the things that figures largely for me as a source of sulfur during this time though is shrimp. I kept thinking it was a safe food to eat, and didn’t realize until later it was a source of sulfur. Additionally, I was taking several supplements that contained sulfur: gelatin, biotin, glutathione, NAC, ALA, MSM. I had gotten into the habit of trying different supplements since 2010 because of a neuralgia that neither doctors nor dentists could explain. Though I was not taking all of them at once, I did supplement enough to assume I kept my sulfur level high throughout this time period.
I noticed the thread Red Ringlets posted at 23&me in August of 2013. In October I asked whether or not sulfur could cause a dehydrating effect. I asked this because I’ve noticed wine can take more water out of me than other drinks containing alcohol do. I didn’t get an answer to that question, but I began to explore some of the links people had put into the thread. I read through this site: www.learningtarget.com. I found the following page particularly helpful because it mentioned that molybdenum is a vital part of the sulfite oxidase enzyme: Vitamins and Supplements for Sulfite Problems.
I still had not made a connection between sulfur and irritable bowel syndrome, but I decided to supplement with fucoidan, which is a sulfated polysaccharide found in some seaweeds. I thought it would help my gut, but it caused diarrhea. It was as if I had decided to supplement with cholera. The effect was large and obvious enough for me to realize it was probably the supplement I had just taken. Once I accepted that, I put together what I had learned from the 23&me thread.
Now, in retrospect, I think fucoidan may have caused diarrhea for completely different reasons. I learned in my 23&me health report that I am norovirus resistant, and I have subsequently read that this has something to do with my ability (or inability) to make fucose. I can’t remember where I read this, but it made me think fucoidan could have destabilized my gut flora for reasons unrelated to its sulfur content.
Whatever the reason for the extreme reaction to fucoidan, I decided the beneficial reaction to molybdenum meant that I had a genetically limited capacity to deal with all the extra sulfur in my food and supplements. I threw out my high sulfur supplements and tried to stick to low sulfur foods. Within about two weeks I started having normal bowel movements. This was better than what I was achieving before the entire fucoidan fiasco. I had migrated to a diet of rice and fish which helped me approximate normalcy, but any time I tried to have any variety in my diet, I would run into problems. By avoiding sulfur, I was able to eat a larger variety of foods without incident.
Eventually I found if I was very careful, I could eat small amounts of high sulfur foods, but this is hit or miss because I can’t reliably gauge what the potential dose is, nor is it always clear whether a food has sulfur in it. I still supplement with molybdenum but I think the long term strategy here is both molybdenum and at least avoiding high sulfite foods because my genetics suggest it is doubtful I am going to be able to process as many sulfites as other people do regardless of how much molybdenum I have.
As I mentioned before, I think once the gut is compromised, many things become irritants. Removing excess sulfur has increased my health a lot, but I suspect I need to improve gut flora, and possibly heal some tissue damage. The doctors may not be able to see it, but I still have residual pain in the region where my appendix is.

This entry was posted on Thursday, April 3rd, 2014 at 5:00 am and is filed under journal of personal science. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

10 Responses to “Journal of Personal Science: Molybdenum and Avoiding Sulfur Helped My IBS”

August Says:
April 3rd, 2014 at 7:51 am “I read through this site: sulfite oxidase enzyme:”
Originally was
“I found the page below particularly helpful because it mentioned Molybdenum is a vital part of the sulfite oxidase enzyme”
And it looks like this other link completely disappeared:
http://www.learningtarget.com/nosulfites/>www.learningtarget.com
JM Says:
April 3rd, 2014 at 12:03 pm August, great example of using careful observation and personal science to diagnose and treat yourself – and I think it’s pretty obvious that traditional medicine would never have figured this out. And thanks for sharing, maybe this will help someone else who is having similar problems.
August Says:
April 3rd, 2014 at 1:50 pm Thanks JM.
It looks like I need to correct my correction. The link is:
http://www.learningtarget.com/nosulfites/
dr j Says:
April 3rd, 2014 at 2:52 pm Dear August,
Thank you for taking the time to write about your inspiring detective work! Its is extremely valuable to be able to mull over your process in approach; i am starting on a Lynch Syndrome path.
best
john
Steve Says:
April 3rd, 2014 at 6:22 pm August:
I just checked my 23&me data. My results are the exactly the same as Red Ringlets and yours: SUOX rs10876864 AA, rs705703 CC, i5000977 AA, i5000976 AA . That would finally explain why I get such intense headaches when I drink red wine.
Seth Roberts Says:
April 4th, 2014 at 1:48 pm Sorry. It appeared correctly in the visual editor.
JRM Says:
April 6th, 2014 at 9:27 am I started supplementing with molybdenum after I did a hair minerals analysis test which showed very low levels of molybdenum. I felt better. 23andme said that I was a slow metabolizer of caffeine. Molybdenum is used in caffeine detoxification via xanthine oxidase. Supplementation helped reduce caffeine withdrawal symptoms the next day.
The farmer who I buy almost all of my beef from commented that my hair test was similar to his soil minerals test. A different local farmer commented that her soil minerals test showed a deficiency in molybdenum. When I go to the farmer’s market, I find that asking farmers if they do soil mineral tests and supplementation is a good indicator of whether their food will taste good. The best farmers test beyond ph, Ca, Mg, N, P, K to a plethora of micronutrients Mo, Se, Fe, Cu, Zn, B, Mn, Cr, Co, etc. Soil mineral deficiencies become mineral deficiencies in the plants and animals grown on that soil. People can’t go to nutritiondata.com, plug in their daily diet, and assume that their diet contains all the necessary minerals because the website says it should.
One of William Albrecht’s themes was that the soil quality in the South is compromised due to heat and precipitation leaching out the minerals from the soil. Maybe it is coincidence that the author is from the South. I don’t know.
Other minerals which were low on the test like lithium (5 mg/day) and magnesium (via MgCl foot baths), I also noticed a benefit from supplementing. But I haven’t noticed a benefit from supplementing selenium.
JRM Says:
April 6th, 2014 at 9:33 am My markers are
SUOX 56398711 i5000976 AA
SUOX 56397916 i5000977 AA
SUOX 56391486 rs705703 CC
intergenic 56401085 rs10876864 AG
I haven’t noticed a reaction to sulfites or sulfur containing foods.
Louis Says:
April 15th, 2014 at 10:41 am Hello, August,
Thanks for writing this article. I imagine you might be helping many people; perhaps you’ve helped me at least. If nothing else, it’s another hypothesis for me to test.
I believe I could have this issue with sulfites, so I’ve begun a low sulfur diet. I too have IBS that got slightly better on a low FODMAP diet, but by no means took care of it completely.
I’m wondering a couple things:
1. You say that you had normal BM’s after two weeks. Did that two week period include supplementing with molybdenum or was that on the low sulfite diet alone?
2. I have a number of symptoms that I think are related to the IBS such as insomnia and difficulty concentrating. Did you too have symptoms related to your IBS? If so, did they go away or show improvement in two weeks too?
Thanks!
Anne Says:
April 18th, 2014 at 12:08 am Hi August
Thank you for taking the time to write down this post. It was really interesting, and I will try this out over the coming weeks. I will start today and take away MSM and instead put in some molyben.
The last entry from Louis was really interesting and I am very intressted in your comments on that, because that is a big thing even for me.
2. I have a number of symptoms that I think are related to the IBS such as insomnia and difficulty concentrating. Did you too have symptoms related to your IBS? If so, did they go away or show improvement in two weeks too?
Kindly
Anne

Friday, 25 April 2014

Lynch Sydrome and Aspirin

the cancer incidence statistics for Sri Lanka show that the lowest number is for Muslim females, while Muslim males have rectal cancer. So find out what Muslim sri Lanka females eat.
April 2014 advance: researchers found that individuals whose colons have high levels of a specific gene product - 15-hydroxyprostaglandin dehydrogenase (15-PGDH) RNA - dramatically reduce their chances of developing colorectal cancer by taking aspirin. In contrast, the analgesic provides no benefit to individuals whose colons show low levels of 15-PGDH
Eat Lesion rich foods: why salycitate is a signalling molecule if a cell has been attacked to other cells.
Eat low Glyphosate foods : ( to be reviewed)
Beware B3/B6 inhibiting foods : Nutrition-dependent GABA deficiencies in endocrine pancreas causes cancer, as shown for betel nut consumers and for diets de-activating vitamin B6 ( OA publishing )

Monday, 21 April 2014

Hair Lustre and Probiotics April Easter 2014

Greta post by Paul
You might be interested in this post https://www.facebook.com/TheSilverHydra/posts/10152383181385281?stream_ref=1
I thought that PLoS study (linked in that FB post) was fascinating. Check out figure one, the hair growth and hair quality is incredible. Have you researched L. reuteri much?

Frank Kurtis facebook page

Food for thought, in the past skin comorbidities and mental health disorders seem to be highly correlated and benefits of probiotics (intestinal bacteria) on the skin seem to use the same mediators as when they benefit the brain.
Although very preliminary, some researchers are extending the whole 'gut-brain axis' thing to be 'gut-brain-skin axis' since they are all interrelated and skin can be used to visually assess (very roughly) the other organs status.
Some free reading:
http://www.ncbi.nlm.nih.gov/pubmed/23886975
http://www.ncbi.nlm.nih.gov/pubmed/21281494
And finally, a cool hypothetical study from PLoS about the whole 'glow of health' interrelating fertility and physical attraction via the gut. The supplement in question is lactobaciullus reuteri, and I'm looking into it currently:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0053867
Basically what I'm trying to say is eat your fiber; it not only makes you pretty but probably makes you smarter.

L. reuteri is the prime agent tested
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0053867

Abstract out of MIT

Radiant skin and hair are universally recognized as indications of good health. However, this ‘glow of health’ display remains poorly understood. We found that feeding of probiotic bacteria to aged mice induced integumentary changes mimicking peak health and reproductive fitness characteristic of much younger animals. Eating probiotic yogurt triggered epithelial follicular anagen-phase shift with sebocytogenesis resulting in thick lustrous fur due to a bacteria-triggered interleukin-10-dependent mechanism. Aged male animals eating probiotics exhibited increased subcuticular folliculogenesis, when compared with matched controls, yielding luxuriant fur only in probiotic-fed subjects. Female animals displayed probiotic-induced hyperacidity coinciding with shinier hair, a feature that also aligns with fertility in human females. Together these data provide insights into mammalian evolution and novel strategies for integumentary health.

Hair washing - Dont forget- condition first, wash after, i wonder if this feeds bacteria near the follicle?

Lucy Colitis Easter April 2014

A Colitis and oral/ Tongue Bacteria Story:
Lucy,a 15 yo jack russell terrier has severe, almost life threatening , occasional bouts of colitis, preceded with mucus on stools.over a 2 day cycle. Broccoli at dinner is a favoured part of her diet. Can we learn from this preference for a green vegetable?

Enter last night this murine model paper- “Preventive and therapeutic effects of nitrite supplementation in experimental inflammatory bowel disease” http://www.sciencedirect.com/science/article/pii/S2213231713001006

Highlights
• Inorganic nitrate and nitrite alleviate DSS-induced colitis.
• Dietary nitrite has therapeutic effects in already established colonic inflammation.
• DSS-induced thinning of the colonic mucus layer is prevented by dietary nitrite.
• Nitrite promotes healing of colon epithelial cells.

Now the interesting part is that circulating nitrate is converted by bacteria on the tongue to nitrite! http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575935/
“The site of nitrate reduction to nitrite in humans is almost exclusively on the posterior third of the tongue, by nitrate reductase‐containing symbiotic bacteria, predominantly Veillonella species, as well as Actinomyces, Rothia and Staphylococcus epidermidis [b117,b118]. Whilst some conversion of nitrate to nitrite occurs on the ‘first pass’ of nitrate‐containing food over the surface of the tongue before it is initially swallowed, the majority of nitrate reduction to nitrite occurs over the subsequent few hours, via the entero‐salivary circulation [1], following concentration of nitrate in the salivary glands, and secretion in saliva, as described above [107,113,115,116].

So the experiment started last night- to lift the amount of nitrate in food and test the palatibility of foods; last night, first test – smoked salmon- eaten with relish. This morning, wilted lettuce with smoked salmon – eaten with relish. So we keep going with finding interesting sources of dietary nitrates.

As an aside, while there is strong interest in repairing the effect of episodic bouts of antibiotics on gut flora, I am increasingly interested in the prospects of continuous insults to flora, via ” innocuous” chloroamines in drinking water to oral bacteria ecology and the reaction in the stomach of amine and nitro compounds.

Now this little story gives a little encouragement to examine the life cycle of dietary recommendations for humans. An example is outlined in this abstract http://www.ncbi.nlm.nih.gov/pubmed/19439460
“Food sources of nitrates and nitrites: the physiologic context for potential health benefits”. The suggested intake is up to 550% greater than guidelines.

Background Notes for oral biome

DSS Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks DSS is a polysaccharide with various MW supplies. Different effects occur with different MW.
Oral bacteria thread , excellent
H Pyroli uses nickel in its enzymes , Stores it, and nickel can come from Stainless steel cutlery and pots

Sepiapterin ameliorates chemically induced murine colitis and azoxymethane-induced colon cancer
C60 forum

Monday, 31 March 2014

Lynch Syndrome Strategy

Lynch Lynch

Our strategy is to 1) think through the effectiveness of 100mg daily enteric coated Aspirin and do a little novelty to hve a gut ecossytem that might manage the mucin releasing cells and 2) look at the gene deletions for dna repair and see if we can find a workaround.

background resource files
question 1 : can we part replace aspirin with low poisonous salicyalte rich foods low in glyphosate?
as poison
in foods and action

Plant hormone

Salicylic acid (SA) is a phenolic phytohormone and is found in plants with roles in plant growth and development, photosynthesis, transpiration, ion uptake and transport. SA also induces specific changes in leaf anatomy and chloroplast structure. SA is involved in endogenous signaling, mediating in plant defense against pathogens.^[4] It plays a role in the resistance to pathogens by inducing the production of pathogenesis-related proteins.^[5] It is involved in the systemic acquired resistance (SAR) in which a pathogenic attack on one part of the plant induces resistance in other parts. The signal can also move to nearby plants by salicylic acid being converted to the volatile ester, methyl salicylate.^[6]

Mechanism of action

Salicylic acid has been shown to work through several different pathways. It produces its anti-inflammatory effects via suppressing the activity of cyclooxygenase (COX), an enzyme that is responsible for the production of pro-inflammatory mediators such as the prostaglandins. It does this not by direct inhibition of COX like most other non-steroidal anti-inflammatory drugs (NSAIDs) but instead by suppression of the expression of the enzyme (via a yet-unelucidated mechanism).^[22] Salicylic acid has also been shown to activate adenosine monophosphate-activated protein kinase (AMPK), and it is thought that this action may play a role in the anticancer effects of the compound and its prodrugs aspirin and salsalate. In addition, the antidiabetic effects of salicylic acid are likely mediated by AMPK activation primarily through allosteric conformational change that increases levels of phosphorylation.^[23] Salicylic acid also uncouples oxidative phosphorylation, which leads to increased ADP:ATP and AMP:ATP ratios in the cell. As a consequence, salicylic acid may alter AMPK activity and subsequently exert its anti-diabetic properties through altered energy status of the cell. Even in AMPK knock-out mice, however, there is an anti-diabetic effect, demonstrating that there is at least one additional, yet-unidentified action of the compound.^[24]

Bacillis as an Agent
Grdening Australia link
Christal site for Lucy
Is something interfering with Trypophan uptake?
Cancer statisitcs in Sri Lanka by Relgion: eat like a moslem female
fungus to control other fungus as ecosystem

Tuesday, 18 March 2014

garlic resources

To contact Longevinex call 1-866 405-4000, email info@longevinex.com, visit www.longevinex.com, www.garlizyme.com

Assessment Of Aggregate Biological Threats & Confirmation Of Garlic As A Natural Remedy For What Ails Modern Civilization

Every day we read or hear about some biological threat, whether it be from a potentially deadly strain of the flu virus, a prevalent pathogenic bacterium in foods like Campylobacter in uncooked chicken meat; or a seemingly safe FDA-approved drug that has been found to be unsafe like aspirin that induces bleeding gastric ulcers and brain hemorrhages; or pollutants in the air or water like the endemic fungus that causes Valley Fever or chlorine that decontaminates our tap water but increases risk for colon cancer; or toxic heavy metals like mercury or lead in our dental fillings and roadways; or parasitic germs like H. pylori, Candida albicans or Streptococcus that are commonly harbored in our own digestive tract.

Then there is aging itself with all of the chronic diseases it brings with it – circulatory problems, insidious decline in vision from cataracts, glaucoma and macular degeneration, as well as fatty liver, excessive sugar levels and numerous malignancies.

Not to mention excitotoxins like MSG, toxic sugars like fructose, hydrogenated (trans) fats in baked goods, carcinogens like nitrosamines, acrylamide or dioxin, or a newly described threat - advanced glycation end products produced from heat-processed sugary foods we eat.

There are endless studies of each and every one of these and many other health threats, but no study that assesses these risks as a whole. Modern medicine addresses each and every one of these health threats individually and capitalizes on all of them by developing costly medicines and narrowly designed treatments that can be found in the voluminous International Classification of Diseases (ICD-volume 9) published by the World Health Organization and in the Merck Manual.

Waiting for each and every one of these threats to occur and then attempting to treat them as they are detected appears to be folly. But that is precisely how modern medicine addresses prevalent health threats and runs up the bill.

Mounting a defense against all biological threats

Mounting a defense against all of them would pose a considerable challenge as well. How many medicines would one have to take to fend off all of them? And in this era of germ resistance, we can't habitually take antibiotics to ward off infectious diseases before they occur without inducing treatment-resistant forms of these germs over time.

Is there anything available that counters all these threats?

If an antidote DOES exist for all these health threats, it must be safe, widely available, not require a doctor's prescription, economical and user friendly. It has to be something that people don't have revulsion over, like the after-taste of cod liver oil.

Vitamins and minerals are essential for health maintenance but there is no single nutrient that addresses all of these health threats.

One antidote: an old remedy

Upon careful examination, nature does provide one antidote for what ails modern society – garlic.

Garlic, in particular its primary active principle – allicin:

Allicin is described as an ideal antioxidant particularly because of its broad application for prevention, therapy and aging.
Garlic controls heavy metals such as lead, copper, cadmium and iron. Garlic is a remedy for fatty liver by virtue of its ability to remove iron. Garlic removes some heavy metals better than mineral-chelating drugs. While some herbal dietary supplements may increase circulating lead levels, garlic does not.
Byproducts of oxygen, nitrogen and metals induce oxidation and damage to DNA and tissues. Garlic neutralizes all oxidants – oxygen free radicals, nitrogen free radicals, singlet oxygen and the dreaded hydroxyl radical.
Garlic does not eradicate beneficial bacteria in the digestive tract.
Garlic counters the effects of environmental chemicals and carcinogens such as dioxin, acrylamide and asbestos.
Garlic counters the effects of poor health habits such as over-consumption of alcohol, tobacco use, and over-consumption of food.
Garlic works synergistically or protectively with many medications, such as statin drugs, antibacterial and antifungal drugs, etc.
Garlic counters the effects of aging on the pancreas, liver, brain, heart, arteries, kidneys and other organs.
Garlic inhibited tumor necrosis factor (TNF) about 47% in one human study. TNF is a master marker of inflammation.
Sulfur compounds in garlic calm and normalize the immune response so that the first arriving white blood cells (neutrophils) do not over-induce inflammation.
Garlic counters the adverse effects of fructose, considered to be a toxic form of sugar.

GARLIC AND INFECTIOUS DISEASE

Garlic protects against food poisoning. (48 million cases a year in U.S.)
Kills off a broad spectrum of germs – bacteria, viruses, fungi, amoeba and protozoa and even ticks and nematodes as well as insect-borne malaria. Garlic molecules eradicate germs effectively without inducing germ resistance. Garlic is more effective than some antibiotics in the treatment of antibiotic resistance bacteria.
The Centers for Disease Control says modern medicine is in the post-antibiotic era and may be entering a point of no return, when man-made antibiotics won't work anymore. Allicin from garlic is posed as a possible answer to antibiotic resistance.
Garlic extract has been demonstrated to protect against influenza viruses in laboratory mice. Given that the effectiveness of the flu vaccine is limited among those most at risk (the very young and the very old) for death from the flu and that most of the time the flu vaccine doesn't match the strain of the flu virus in circulation, this raises the possibility lives are needlessly being lost because modern medicine overlooks garlic.
Overreliance upon vaccines that deliver small amounts of viruses and bacteria in order to provoke antibodies has led to the problem vaccine- derived illness and the realization there will never be complete eradication of communicable diseases because of the fact vaccines have become the primary source of circulating infectious disease today.
Garlic completely eradicates warts with no recurrence reported.
Kills off intestinal parasites such as H. pylori (52% of Americans) and Candida albicans (70% of Americans).
Protects babies from infection in the womb.
Garlic is even effective in eradication of hookworm and tapeworm.

GARLIC AND CANCER

While there are no commonly prescribe cancer preventive agents in use today, there are numerous studies that indicate allicin from garlic inhibits cancer. Garlic protects against carcinogenic nitrosamines in food.

GARLIC AND THE CIRCULATORY SYSTEM

Garlic inhibits the enzyme required to produce cholesterol.
Garlic decalcifies arteries.
Garlic intake is a predictor of whether a person will experience a stroke.
Garlic, particularly fresh-crushed garlic that provides allicin, produces a minute amount of hydrogen sulfide gas that activates internal antioxidant defenses prior to a heart attack, reducing the area of damage should a heart attack occur and turns mortal heart attacks into non-mortal events. [Source: Antioxidants & Redox Signaling 2010]
reduced area of damage to the heart following a heart attack facilitated by garlic-derived hydrogen sulfide gas can be visualized, as shown below.

Garlic, via its ability to generate hydrogen sulfide gas, is a potential treatment for heart failure. Garlic has been demonstrated to improve the blood pumping activity of the heart following chemotherapy-induced heart failure.
Raw crushed garlic cloves yielding allicin, but not cooked garlic, effectively inhibits clumping of blood platelets and is known as a safe anti-blood clotting agent. In one lab dish study allicin completely inhibited blood platelets from clumping to form clots. Allicin, the primary active ingredient in garlic, is a more potent anti-clotting agent than aspirin. In one study no bleeding episodes were recorded among patients taking the blood thinning drug Warfarin and fresh garlic or garlic supplements. In another study, garlic pills did not produce bleeding episodes among genetically vulnerable patients taking Warfarin.

GARLIC AND AGING

Because of its mineral chelating (key-layting) properties, garlic addresses the aging process itself. It is aging that is responsible for most chronic disease.

The Overmineralization Theory of Aging has been proposed. Overmineralization has been called "the malignant spirit in successful aging."

Garlic has been found to prolong the life of roundworms in a model of aging.

Garlic activates internal enzymatic antioxidants via the Nrf2 gene transcription factor – catalase, superoxide dismutase, heme oxygenase and glutathione, which is considered an anti-aging effect.

Garlic addresses the cosmetic side of aging. Garlic provides molecules that have been shown to inhibit skin wrinkling.

GARLIC SAFETY

Garlic is safer and more effective than aspirin.
Garlic is safer than cholesterol-lowering statin drugs.
A survey revealed that 8% of 657 patients taking dietary supplements consumed garlic pills (53 patients) and there were no reported side effects. The authors of this study considered potential drug interactions as "worrisome" but could not identify any instances where garlic produced problems when blood thinners were being used.
A safety review did not find any published reports of adverse effect or mortality associated with garlic.
Garlic does not appear to interfere with drug metabolism.

THE REACH AND IMPACT OF GARLIC

In 1988 a report published in the Journal of the National Medical Association stated that garlic has "played in the therapy of many diseases since time immemorial…. Garlic has been a mainstay in the medicinal arsenal of many past civilizations, including the Egyptian, Hebrew, Chinese, Greek, Indian, Japanese, and Roman…. No other substance, either natural or synthetic, can match garlic's proven therapeutic versatility and effectiveness …. Allicin and other sulfur compounds are thought to be the major antimicrobial factors in garlic… Profound therapeutic and economic implications will evolve as data from studies continue to confirm the medicinal spectra of garlic."

It is agonizing to recognize how long garlic and its primary active molecule allicin have been disregarded in preference for synthetic drugs that have boxed mankind into a corner. The plagues of the Dark Ages may return due to germ resistance emanating from overuse of antibiotics.

Aged garlic extract offers many proven health benefits, but lacks the pungent allicin molecule which is garlic's best studied molecule. In one key study, raw crushed garlic providing allicin, but not boiled or aged garlic, prevented adverse effects upon coronary arteries.

The importance of recognizing and obtaining allicin, its principal active ingredient, particularly because of garlic's germ-fighting properties, has been underscored in this report.

Raw crushed garlic cloves, by virtue of mixing the allicin-activating enzyme alliinase with garlic pulp, reliably produce allicin but because of its pungency and odor poses the problem of throat irritation and garlic breath. The pungency and odor produced by raw garlic cloves is an obstacle to public adoption of this natural remedy. Heating garlic cloves to reduce pungency and odor negates any production of allicin, its key ingredient.

Over a decade ago enteric-coated garlic pills were initially found to reduce circulating cholesterol levels then later failed to do so due to a change in manufacturing. Enteric-coated garlic pills, designed to dissolve in the less acidic intestines rather than the acidic stomach, may not always be a reliable way to produce allicin.

A 2007 trial published in the Archives of Internal Medicine conducted by investigators at Stanford Medical School using raw garlic, garlic powder, aged garlic extract failed to demonstrate a statistical or clinically significant effect upon cholesterol. This report generated negative news reports and a decline in the public's interest in garlic at that time.

(Since that time cholesterol has been authoritatively dismissed as a predictor of impending heart attacks and arterial calcifications have been identified as the primary cause of mortal heart attacks. A large human trial published in the European Heart Journal recently reveals high blood pressure, cholesterol or diabetes have no bearing on whether a person will experience a future heart attack while a calcium arterial score of zero indicates an individual has a one-half-of-one percent risk of experiencing a mortal heart attack over a 5-year period. This is another giant misdirection by modern medicine. Garlic therapy has been shown to reduce calcification of coronary arteries.)

Meanwhile, the challenge of overcoming garlic's pungency and odor while delivering allicin, its key molecule, has finally been overcome. The availability of an alkaline buffered garlic capsule that assuredly delivers about 2500-2800 micrograms (2-3 milligrams) of allicin, about the same amount as a fresh-crushed clove of garlic, and that also eliminates garlic breath and odor, is a welcome development.

Will adoption of this garlic pill into people's daily health regimens occur? If so, a favorable change in health status and longevity in the population at large may be forthcoming.

Given the many published reports extolling garlic, its lack of adoption by modern medicine is a major oversight. Predictably, there will be no doctor-led garlic revolution. Despite the overwhelming evidence and historical use of garlic, cholesterol-lowering statin drugs have been the central focus of the practice of medicine for the past 30 years.

An assessment of aggregate health threats provides a more comprehensive view of health threats that humans face on a daily basis. The practice of addressing each and every biological threat as they occur has led to point where the cost of medical care is beyond affordability.

While the broad biological action of vitamin D and polyphenols such as resveratrol, curcumin, quercetin and catechin are just now being realized, garlic-derived allicin is posed as the most comprehensive, economical agent that could usher in an era of truly preventive medicine. ©2014 Bill Sardi, Knowledge of Health, Inc. Disclosure: Bill Sardi has a financial interest in dietary supplements.

Wednesday, 13 August 2014

Sunday, 13 July 2014

Monday, 7 July 2014

Tuesday, 1 July 2014

Muscle repair via stem cell stimulation

Abstract

Low Oxytocin, Liver and Oxytocinase Activity

from this paper J Endocrinol. 2014 Feb 10;220(3):333-43.

Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue.

Oxytocin reverses ovariectomy-induced osteopenia and body fat gain.

Treatment of Obesity and Diabetes Using Oxytocin or Analogs in Patients and Mouse Models

Impact of growth hormone (GH) deficiency and GH replacement upon thymus function in adult patients.

Abstract

BACKGROUND:

METHODOLOGY/PRINCIPAL FINDINGS:

CONCLUSIONS:

TRIAL REGISTRATION:

Wednesday, 25 June 2014

Thursday, 12 June 2014

Monday, 26 May 2014

Monday, 19 May 2014

Sunday, 18 May 2014

1 to 20 of 22

Wednesday, 30 April 2014

Tuesday, 29 April 2014

by August Hurtel

10 Responses to “Journal of Personal Science: Molybdenum and Avoiding Sulfur Helped My IBS”

Friday, 25 April 2014

Monday, 21 April 2014

Abstract out of MIT

Hair washing - Dont forget- condition first, wash after, i wonder if this feeds bacteria near the follicle?

Background Notes for oral biome

Friday, 11 April 2014

Monday, 31 March 2014

Plant hormone

Mechanism of action

Tuesday, 18 March 2014

Mounting a defense against all biological threats

One antidote: an old remedy

GARLIC AND INFECTIOUS DISEASE

GARLIC AND CANCER

GARLIC AND THE CIRCULATORY SYSTEM

GARLIC AND AGING

GARLIC SAFETY

THE REACH AND IMPACT OF GARLIC